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Growth factor beta-3 (GFB-3), which promotes angiogenesis (formation of new blood vessels) and metastasis in breast cancer cells. This Smad pathway modulates GFB-3 to form inhibitory Smads (Smads 2, 3, and 7). The modulated Smads can either increase GFB-3 protein levels, decreased GFB-3 protein levels, or prevent GFB-3 protein synthesis and its regulation. click over here This Smad pathway modulates GFB-

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