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Subject: Hexokinase vs Glucokinase: Which Is More Important for Beta-Cell Function [MCAT Quiz] Both glucokinase and hexokinase are important enzymes in the beta-cell, and they regulate insulin secretion in the pancreas. Glucokinase is the main enzyme responsible for the rate of glucose utilization in the beta-cell, while hexokinase is a second enzyme responsible for the phosphorylation of

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