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As the only 2-HBA is a non-selective enzyme, it plays a vital role in catalyzing the assembly and disassembly of nucleosomes in response to DNA damage. In addition, DNA damage can trigger ATP-dependent nucleosome sliding, which is a process of nucleosome relaxation, ATP depletion, and chromatin sliding that plays a crucial role in controlling DNA replication and chromatin condensation. To better understand how ATP-dependent nucleosome sliding works, you may want to

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The molecular machinery of the DNA replication and transcription are controlled by the core DNA replication fork and the specific nucleosome assembly complex. The molecular machinery of these processes is regulated at various stages, including initiation of replication, promotion of elongation, termination of DNA synthesis, and stabilization of the replication and transcription complexes. The process of ATP-dependent chromatin remodeling, also known as ATP-dependent chromatin sliding, refers to a general class of molecular mechanisms that are

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